Sertraline for Premature Ejaculation

Sertraline is a prescription medication that doctors can prescribe for the treatment of premature ejaculation, allowing you to control your climax and enjoy sex for longer. And because sertraline is a pill taken daily, you won’t have to halt the action to apply a topical product. Modern romance at its finest.
IMPORTANT SAFETY INFORMATION

* Sertraline is not FDA-approved for the treatment of premature ejaculation. Learn about 'off-label uses' * Some side effects can be serious. If you experience any of the following symptoms call your doctor immediately: seizures, abnormal bleeding or bruising, agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea, rash, hives, swelling or difficulty breathing. Read less

What is premature ejaculation?

Premature ejaculation (or “PE,” for short) is defined as a “persistent or recurrent ejaculation with minimal stimulation before, on or shortly after penetration and before the person wishes it.” In simple terms, premature ejaculation occurs when you ejaculate too early during intercourse or sexual activity. There’s no specific amount of time that defines ejaculation as “premature”—most sources use figures ranging from 30 seconds to four minutes into sexual activity.

Why Sertraline?

Sertraline, the active ingredient in Zoloft, is a selective serotonin reuptake inhibitor (SSRI) that helps increase the serotonin levels in your brain. Since serotonin is part of how your brain processes sexual excitement, SSRIs like sertraline can help manage premature ejaculation during the times that count, without numbing the penis.

How to take

Sertraline for premature ejaculation is taken daily. Simply take your medication at the same time every day with or without food. Always take sertraline exactly as prescribed by your doctor.

Prescription pills or pej spray?

Prescription medicine for premature ejaculation, such as sertraline, and topical products like Hims Climax Delay Spray can both help increase time to ejaculation--but work differently and fit different lifestyles. Since sertraline is a pill, it might be a good fit for people worried about having to plan sex or stop in the middle of the action to spray or wipe the penis. Climax Delay Spray, on the other hand, might be a good fit for people who don't want to take a prescription pill.

Stay safe

Consult your doctor about any medications, supplements, or vitamins you may take in case of drug interactions with SSRIs. Additionally, make sure to read all of the important safety information before you start sertraline and use our platform to talk with a doctor if you are experiencing side effects that concern you or don’t go away. Click here for a list of the most common side effects.

Important Safety Information

Consult your doctor about any medications, supplements, or vitamins you may take in case of drug interactions with SSRIs. Additionally, make sure to read all of the important safety information before you start sertraline and use our platform to talk with a doctor if you are experiencing side effects that concern you or don’t go away. Click here for a list of the most common side effects.

FAQs

For any additional questions, please reach out to info@onehealth.com. We can also be reached by phone at +44 116 228 8600, Monday – Friday, 8am-6pm EST.
How does prescription PE treatment work with One Health?
Roman is a telemedicine company that provides a discreet, convenient, and affordable way for you to receive PE treatment from a doctor or nurse practitioner—all without leaving the couch. Roman Swipes are available for purchase directly from the website as an over-the-counter (OTC) product that does not require a prescription. If you are interested in prescription treatment, it starts with an online visit. The online visit will ask you about your symptoms, your medical history, and other basic information. You’ll also be asked to upload a photo of your ID to verify your identity. Once you have done all of this, a doctor or nurse practitioner will review everything, determine if you’re a candidate for PE treatment through telemedicine, and craft a personalized treatment plan for you.
Is PE medication effective?
Although no single treatment works for everyone, most men can be treated successfully. There are multiple oral medications, topical therapies, and other techniques that can be used alone or in combination with one another. Some people see immediate results, but for many men it takes some time before results are apparent. Some may find they need to try a few different methods before finding the right solution. If things don’t go as planned or if you experience an adverse side effect, don’t give up. You have options and we are here to help you find the best solution.
Why is ED medication sometimes prescribed for PE?

There are many possible causes of PE, ranging from physical causes to psychological causes. Although it may seem odd to get prescribed ED medication for PE, numerous studies have shown that it can be effective. There are a few reasons ED medication might help:

  • ED medication can help relax the smooth muscles of organs involved in ejaculation
  • ED medication can affect the nervous system in ways that may delay ejaculation
  • ED medication may decrease the sensitivity of the penis
  • ED medication can prolong the duration of an erection, increasing confidence, the perception of ejaculatory control, and overall sexual satisfaction
  • ED medication can make it easier to get a second erection after ejaculation

Some patients may also have coexisting ED and PE. For these patients, it is recommended ED get treated first, to see if it has beneficial effects on PE.

There are also other important differences between the medications. For example, sildenafil citrate is less effective when taken with food and it can cause temporary blue vision (as if you’re looking through blue-tinted glasses) in some users. Tadalafil can be taken with food and is much less likely to cause temporary blue vision in users. Tadalafil can also be taken daily at lower doses.

What are the non-prescription options for treating PE?

Your doctor or nurse practitioner may recommend a combination of medication and behavioral therapy tips to deal with PE. No two people are alike, and it may take time and experimentation to find the methods that work best for you. Some recommended non-prescription techniques include:

  • Topical anesthetics: Topical anesthetics can be applied to the penis just before sexual activity. They come as creams, lotions, or sprays and are available over-the-counter. The advantage of topical applications is that the side effect rate is low.
  • Condoms: Condoms can help with PE by decreasing penile sensitivity. They also have the added benefit of reducing the risk of sexually transmitted infections and unwanted pregnancy.
  • Behavioral modification: The squeeze and stop-start techniques are two different strategies that can be practiced during masturbation or sexual activity, and—over time—they can improve control over the timing of ejaculation.

Psychotherapy: Counseling, whether in person, by telephone, or by text messaging, may increase the likelihood of success for some patients.

Will ED medication automatically give me an erection?

There are three prescription-strength medications for PE available on the Roman platform: sildenafil citrate (the active ingredient in Viagra), tadalafil (the active ingredient in Cialis), and sertraline (a type of medication known as a selective serotonin reuptake inhibitor, or SSRI). Your doctor or nurse practitioner will decide which treatment option is most appropriate for you after reviewing the information you provide in your online visit. While one medication may be better for one person, a different medication may be better for another person. It all depends on your specific medical history, symptoms, and preferences. Of note, there is no medication that is specifically FDA-approved for the treatment of PE. However, sildenafil citrate, tadalafil, and sertraline can be prescribed off-label for this purpose, if appropriate.

In addition to these three prescription medications, Roman Swipes is an over-the-counter treatment for PE that you can purchase directly from the website without going through an online visit.

What is off-label usage of a medication?
Off-label usage of a medication refers to using the medication for purposes that have not specifically been approved by the FDA. Healthcare professionals have the discretion to prescribe medications off-label if they believe it is an appropriate course of treatment for a particular patient.
How is sertraline used to treat PE?
Sertraline can be used in two ways to treat PE. It can be taken daily at a convenient time (e.g., after brushing your teeth in the morning) or it can be taken as-needed 4–8 hours before you plan to have sex. Studies have found that taking the medication daily is generally more effective than taking it as needed. However, taking the medication daily also increases the risk of experiencing side effects. Your doctor or nurse practitioner can work with you to help determine if daily or as-needed dosing is best for you.
Can I use Roman Swipes along with prescription treatment?
Yes. Using Roman Swipes in combination with prescription treatment is not dangerous and can actually help delay ejaculation even more. This is especially good for patients who do not see enough of a benefit from prescription medication alone. On the other hand, some people will find that the combination delays ejaculation too much, decreasing satisfaction for them or their partner(s).

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Sertraline – Important Safety Information

WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS

Sertraline and other antidepressant drugs may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when sertraline is started or when the dose is changed.

Who should not take sertraline?

Do not take sertraline if:

You take a Monoamine Oxidase Inhibitor (MAOI), including linezolid or methylene blue, or if you stopped taking an MAOI in the last 2 weeks. Do not take an MAOI within 2 weeks of stopping sertraline. Ask your healthcare provider or pharmacist if you are not sure if your medicine is an MAOI. People who take sertraline close in time to an MAOI may have serious or even life threatening side effects.

Get medical help right away if you have any of these symptoms:

  • high fever
  • uncontrolled muscle spasms
  • stiff muscles
  • rapid changes in heart rate or blood pressure
  • confusion
  • loss of consciousness (pass out)

Take Orap® (pimozide) because this can cause serious heart problems

Take MELLARIL® (thioridazine) because this can cause serious heart rhythm problems or sudden death.

Are allergic to sertraline or any of the ingredients in sertraline

Sertraline and other antidepressant medicines may cause serious side effects. Call a healthcare provider right away if you or a person you know who is taking sertraline has any of the following symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide
  • Acting aggressive or violent
  • New or worse depression
  • Feeling agitated, restless, angry, or irritable
  • An increase in activity or talking more than what is normal for you
  • Acting on dangerous impulses
  • Thoughts about suicide or dying
  • New or worse anxiety or panic attacks
  • Trouble sleeping
  • Other unusual changes in behavior or mood
  • Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.

Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.

What should I tell my healthcare provider before taking sertraline?

Before taking sertraline, tell your healthcare provider and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including:

  • those to treat migraines
  • psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome
  • Aspirin
  • other NSAID pain relievers
  • other blood thinners because they may increase the risk of bleeding
  • drugs used to treat irregular heartbeat
  • drugs used to treat HIV infection
  • drugs used to treat epilepsy

Before taking sertraline, tell your healthcare provider your complete list of medical conditions, including if you have liver problems, kidney problems, heart problems, seizures or convulsions, psychiatric disorders including bipolar disorder or mania, low sodium levels in your blood, history of a stroke, high blood pressure, bleeding problems, or glaucoma (high pressure in the eye).

Tell your healthcare provider immediately if you

  • Become severely ill and have some or all of these symptoms: agitation, hallucinations, coma, or other changes in mental status; coordination problems or muscle twitching (overactive reflexes); racing heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting, or diarrhea; muscle tightness, as these may be the symptoms of a life-threatening condition called Serotonin Syndrome
  • Have a rash, hives, swelling, or trouble breathing as these may be the symptoms of an allergic reaction
  • Have seizures or convulsions
  • Have any increased or unusual bruising or bleeding, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin
  • Have a headache; weakness or feeling unsteady; confusion, problems concentrating, thinking, or remembering, as these may be the symptoms of low salt (sodium) levels in the blood (hyponatremia). Elderly people may be at greater risk for this

Do not stop sertraline without first talking to your healthcare provider. Stopping sertraline may cause serious symptoms, including anxiety, irritability, high or low mood, feeling restless or sleepy; headache, sweating, nausea, dizziness; electric shock-like sensations, shaking, and confusion.

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Should I avoid any activities while taking sertraline?

Sertraline can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how sertraline affects you.

Drinking alcohol while taking sertraline is not recommended.

What are the possible side effects of sertraline in adults?

The most common side effects in adults treated with sertraline include:

  • Nausea, loss of appetite, diarrhea, or indigestion
  • Increased sweating
  • Tremor or shaking
  • Agitation
  • Change in sleep habits including increased sleepiness or insomnia
  • Sexual problems including decreased libido and ejaculation failure
  • Feeling tired or fatigued
  • Weakness
  • Dizziness
  • Sexual problems
  • Dry mouth
  • Constipation
  • Infection
  • Feeling anxious or trouble sleeping

Contact your healthcare provider if you have any side effect that continues or bothers you. These are not all the possible side effects of sertraline. Contact your healthcare provider or pharmacist if you need more information.

For medical advice on side effects, contact your healthcare provider. You can also report side effects to the FDA at 1-800-FDA-1088.

Your healthcare provider or pharmacist can tell you if it is safe to take sertraline with your other medicines. Do not start or stop any medicine while taking sertraline without talking to your healthcare provider first.

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